iReceptor

Felix Breden and Jamie Scott

Abstract

In as recent as the past 2 years university and biomedical research laboratories across Canada have been using “next generation” techniques to produce 100s of millions of sequences characterizing the antibody and T-cell receptor immune response from individuals in vaccine trials, and from patients with autoimmune diseases and cancer. Curating these massive amounts of genomic “Big Data” in one central repository is impractical, and thus at present it is not possible to compare the development of the immune response under different conditions, such as vaccine trials and disease conditions. The iReceptor Gateway will link Canadian and international antibody and T-cell receptor databases, thus allowing the query of these databases for sequences satisfying specific criteria. In addition, iReceptor will develop web services for the sophisticated analysis of these next generation sequencing data from the immune response.